Abstract Epithelia are tightly connected cellular sheets, that shield our body from the external environment.They are continuously maintained by a pooled population of undifferentiated cells through differentiation.However, the maintenance mechanisms remain incompletely understood due to the difficulty of experimentally observing the differentiatio
Background: Fast, effective, and rapid processing of central nervous system (CNS) tissue with good preservation of myelin, especially in tissue from diseased mice, is important to many laboratories studying neurosciences.New method: In this paper, we describe a new method to process and embed CNS tissue from mice.Spinal cords and optic nerves from
Abstract Background Neuroinflammation has an important role Toothbrushes in the pathophysiology of migraine, which is a complex neuro-glio-vascular disorder.The main aim of this review is to highlight findings of cortical spreading depolarization (CSD)-induced neuroinflammatory signaling in brain parenchyma from the inflammasome perspective.In addi
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers.Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a variety of cancers.However, a novel therapeutic approach is needed to further improve patient outcome with these agent
Diamond-like carbon (DLC) films had been formed as a surface treatment for intracorporal device for decreasing the coefficient of friction.DLC pedal plate film showed significant stability without being damaged during acid immersion and high-pressure steam sterilization.However, bacteria that adhere to medical devices lead to the induction of infec